With the publication of The Social Frameworks of Knowledge? the English speaking world has at last been given a serious opportunity to approach the complex sociological thought of Georges Gurvitch. However, as the author himself admits in the Preface, this book appears ?abstract and schematic particularly to the uninitiated?.1 The aim of this paper will be to try to relate this translated work to the main body of Gurvitch's writing and particularly to his stance in the sociology of knowledge. First (...) I will examine the intellectual origins of his sociology of knowledge and his attitude to his predecessors in the field. Secondly I will compare his approach to the sociology of knowledge to that of P. L. Berger and T. Luckmann. (shrink)

Martin Heidegger's explication of Pindar's assertion that ‘to glorify was the essence of poetry’ puts it quite well. He tells us that for Pindar the word does not derive its force from what is already complete in itself. For then man would be glorifying what is already glorious, that which already has the power to impress men. At best the word then would denote an acknowledgment or a confession of being impressed. Instead, he insists, the word denotes the power (...) of making to appear, or to extol a place. 1. (shrink)

This article discusses the ‘nature’ of our contemporary fascination with wildness, in light of the popular documentary “Grizzly Man.”Taking as its central point of departure the film’s central protagonist Timothy Treadwell’s fascination with wild grizzlies and director Werner Herzog’s condemnation of it as gross anthropomorphism, this paper will explore the context and basis of our contemporary fascination with wildness in terms of the current debate raging within environmental philosophy between the social constructivist or postmodern position as exemplified by Martin (...) Drenthen and the feral humanist position as articulated by Paul Shepard.The former argues that this fascination with wildness is reflective of certain historical and cultural trends within contemporary western society, while the latter argues that it is reflective of our primordial human heritage. (shrink)

While outcomes for children with T-cell acute lymphoblastic leukemia have improved dramatically, survival rates for patients with relapsed/refractory disease remain dismal. Prior studies indicate that glucocorticoid resistance is more common than resistance to other chemotherapies at relapse. In addition, failure to clear peripheral blasts during a prednisone prophase correlates with an elevated risk of relapse in newly diagnosed patients. Here we show that intrinsic GC resistance is present at diagnosis in early thymic precursor T-ALLs as well as in a subset (...) of non-ETP T-ALLs. GC-resistant non-ETP T-ALLs are characterized by strong induction of JAK/STAT signaling in response to interleukin-7 stimulation. Removing IL7 or inhibiting JAK/STAT signaling sensitizes these T-ALLs, and a subset of ETP T-ALLs, to GCs. The combination of the GC dexamethasone and the JAK1/2 inhibitor ruxolitinib altered the balance between pro- and anti-apoptotic factors in samples with IL7-dependent GC resistance, but not in samples with IL7-independent GC resistance. Together, these data suggest that the addition of ruxolitinib or other inhibitors of IL7 receptor/JAK/STAT signaling may enhance the efficacy of GCs in a biologically defined subset of T-ALL.Leukemia advance online publication, 30 May 2017; doi:10.1038/leu.2017.136. (shrink)

Belnap–Dunn’s relevance logic, $\textsf{BD}$, was designed seeking a suitable logical device for dealing with multiple information sources which sometimes may provide inconsistent and/or incomplete pieces of information. $\textsf{BD}$ is a four-valued logic which is both paraconsistent and paracomplete. On the other hand, De and Omori, while investigating what classical negation amounts to in a paracomplete and paraconsistent four-valued setting, proposed the expansion $\textsf{BD2}$ of the four valued Belnap–Dunn logic by a classical negation. In this paper, we introduce a four-valued expansion (...) of BD called ${\textsf{BD}^\copyright }$, obtained by adding an unary connective ${\copyright }\,\$ which is a consistency operator (in the sense of the Logics of Formal Inconsistency, _LFI_s). In addition, this operator is the unique one with the following features: it extends to $\textsf{BD}$ the consistency operator of LFI1, a well-known three-valued _LFI_, still satisfying axiom _ciw_ (which states that any sentence is either consistent or contradictory), and allowing to define an undeterminedness operator (in the sense of Logic of Formal Undeterminedness, _LFU_s). Moreover, ${\textsf{BD}^\copyright }$ is maximal w.r.t. LFI1, and it is proved to be equivalent to BD2, up to signature. After presenting a natural Hilbert-style characterization of ${\textsf{BD}^\copyright }$ obtained by means of twist-structures semantics, we propose a first-order version of ${\textsf{BD}^\copyright }$ called ${\textsf{QBD}^\copyright }$, with semantics based on an appropriate notion of four-valued Tarskian-like structures called $\textbf{4}$ -structures. We show that in ${\textsf{QBD}^\copyright }$, the existential and universal quantifiers are interdefinable in terms of the paracomplete and paraconsistent negation, and not by means of the classical negation. Finally, a Hilbert-style calculus for ${\textsf{QBD}^\copyright }$ is presented, proving the corresponding soundness and completeness theorems. (shrink)

Belnap–Dunn’s relevance logic, $\textsf{BD}$, was designed seeking a suitable logical device for dealing with multiple information sources which sometimes may provide inconsistent and/or incomplete pieces of information. $\textsf{BD}$ is a four-valued logic which is both paraconsistent and paracomplete. On the other hand, De and Omori, while investigating what classical negation amounts to in a paracomplete and paraconsistent four-valued setting, proposed the expansion $\textsf{BD2}$ of the four valued Belnap–Dunn logic by a classical negation. In this paper, we introduce a four-valued expansion (...) of BD called ${\textsf{BD}^\copyright }$, obtained by adding an unary connective ${\copyright }\,\$ which is a consistency operator (in the sense of the Logics of Formal Inconsistency, _LFI_s). In addition, this operator is the unique one with the following features: it extends to $\textsf{BD}$ the consistency operator of LFI1, a well-known three-valued _LFI_, still satisfying axiom _ciw_ (which states that any sentence is either consistent or contradictory), and allowing to define an undeterminedness operator (in the sense of Logic of Formal Undeterminedness, _LFU_s). Moreover, ${\textsf{BD}^\copyright }$ is maximal w.r.t. LFI1, and it is proved to be equivalent to BD2, up to signature. After presenting a natural Hilbert-style characterization of ${\textsf{BD}^\copyright }$ obtained by means of twist-structures semantics, we propose a first-order version of ${\textsf{BD}^\copyright }$ called ${\textsf{QBD}^\copyright }$, with semantics based on an appropriate notion of four-valued Tarskian-like structures called $\textbf{4}$ -structures. We show that in ${\textsf{QBD}^\copyright }$, the existential and universal quantifiers are interdefinable in terms of the paracomplete and paraconsistent negation, and not by means of the classical negation. Finally, a Hilbert-style calculus for ${\textsf{QBD}^\copyright }$ is presented, proving the corresponding soundness and completeness theorems. (shrink)

For more than thirty years the writings and influence of one man in particular have dominated and directed the field of modern business ethics. We are indebted to two of his fellow‐Americans for this portrait of Richard T. De George. R. Edward Freeman is the Elis and Signe Olsson Professor of Business Administration and Director of the Olsson Center for Ethics at The Darden School, University of Virginia, Charlottesville, VA 22906‐6550; and Martin Calkins, SJ, is a Research Assistant in (...) the Olsson Center and a doctoral student in business ethics at the Darden School. (shrink)

BackgroundPreprint usage is growing rapidly in the life sciences; however, questions remain on the relative quality of preprints when compared to published articles. An objective dimension of quality that is readily measurable is completeness of reporting, as transparency can improve the reader’s ability to independently interpret data and reproduce findings.MethodsIn this observational study, we initially compared independent samples of articles published in bioRxiv and in PubMed-indexed journals in 2016 using a quality of reporting questionnaire. After that, we performed paired comparisons (...) between preprints from bioRxiv to their own peer-reviewed versions in journals.ResultsPeer-reviewed articles had, on average, higher quality of reporting than preprints, although the difference was small, with absolute differences of 5.0% [95% CI 1.4, 8.6] and 4.7% [95% CI 2.4, 7.0] of reported items in the independent samples and paired sample comparison, respectively. There were larger differences favoring peer-reviewed articles in subjective ratings of how clearly titles and abstracts presented the main findings and how easy it was to locate relevant reporting information. Changes in reporting from preprints to peer-reviewed versions did not correlate with the impact factor of the publication venue or with the time lag from bioRxiv to journal publication.ConclusionsOur results suggest that, on average, publication in a peer-reviewed journal is associated with improvement in quality of reporting. They also show that quality of reporting in preprints in the life sciences is within a similar range as that of peer-reviewed articles, albeit slightly lower on average, supporting the idea that preprints should be considered valid scientific contributions. (shrink)

Like _Beyond All Appearances_,_ _which it supplements, Paul Weiss’s new book is a fundamental work which faces all the hard issues which are not only at the heart of philosophy but at the core of our entire culture. Readers of Mr. Weiss’s phenomenology of religion will need no introduction to this new work which expands and clari­fies many of the issues raised in _Beyond All Appearances. _However, no knowl­edge of Paul Weiss’s previous books is required to understand and appreciate this (...) brilliant new exposition. Weiss’s plain style makes his ideas accessible to all intelligent readers, whether or not they have been trained as professional philosophers. Here in _First Considerations _Mr. Weiss addresses himself to such topics as actuality, internalization, evidence, names, substance, being, natures and possibilities, existence, unity and the cosmos—issues which have engrossed him as a moral philosopher and meta­physician throughout his distinguished career. In his progress through the ideas and issues expounded in this new book Mr. Weiss is concerned with the human condition distinctive of this species of ours. Rigorously applied, his moral philosophy is as complete and thorough as that of any of the major thinkers, and provides as complete a guide as, for example, that of Buddhism. A highly original work, no doubt well in advance of current trends in philosophy, _First Considerations _will provoke further thought and discussion and will be regarded as a seminal work in modern philosophical approaches. (shrink)

Background: Although convolutional neural networks (CNNs) achieve high diagnostic accuracy for detecting Alzheimer’s disease (AD) dementia based on magnetic resonance imaging (MRI) scans, they are not yet applied in clinical routine. One important reason for this is a lack of model comprehensibility. Recently developed visualization methods for deriving CNN relevance maps may help to fill this gap as they allow the visualization of key input image features that drive the decision of the model. We investigated whether models with higher accuracy (...) also rely more on discriminative brain regions predefined by prior knowledge. Methods: We trained a CNN for the detection of AD in N = 663 T1-weighted MRI scans of patients with dementia and amnestic mild cognitive impairment (MCI) and verified the accuracy of the models via cross-validation and in three independent samples including in total N = 1655 cases. We evaluated the association of relevance scores and hippocampus volume to validate the clinical utility of this approach. To improve model comprehensibility, we implemented an interactive visualization of 3D CNN relevance maps, thereby allowing intuitive model inspection. Results: Across the three independent datasets, group separation showed high accuracy for AD dementia versus controls (AUC ≥ 0.91) and moderate accuracy for amnestic MCI versus controls (AUC ≈ 0.74). Relevance maps indicated that hippocampal atrophy was considered the most informative factor for AD detection, with additional contributions from atrophy in other cortical and subcortical regions. Relevance scores within the hippocampus were highly correlated with hippocampal volumes (Pearson’s r ≈ −0.86, p < 0.001). Conclusion: The relevance maps highlighted atrophy in regions that we had hypothesized a priori. This strengthens the comprehensibility of the CNN models, which were trained in a purely data-driven manner based on the scans and diagnosis labels. The high hippocampus relevance scores as well as the high performance achieved in independent samples support the validity of the CNN models in the detection of AD-related MRI abnormalities. The presented data-driven and hypothesis-free CNN modeling approach might provide a useful tool to automatically derive discriminative features for complex diagnostic tasks where clear clinical criteria are still missing, for instance for the differential diagnosis between various types of dementia. (shrink)

Peter Abelard (1079–1142 ce) was the most wide‐ranging philosopher of the twelfth century. He quickly established himself as a leading teacher of logic in and near Paris shortly after 1100. After his affair with Heloise, and his subsequent castration, Abelard became a monk, but he returned to teaching in the Paris schools until 1140, when his work was condemned by a Church Council at Sens. His logical writings were based around discussion of the “Old Logic”: Porphyry's Isagoge, aristotle'S Categories and (...) On Interpretation and boethius'S textbook on topical inference. They comprise a freestanding Dialectica (“Logic”; probably c.1116), a set of commentaries (known as the Logica [Ingredientibus], c. 1119) and a later (c. 1125) commentary on the Isagoge (Logica Nostrorum Petititoni Sociorum or Glossulae). In a work Abelard called his Theologia, issued in three main versions (between 1120 and c.1134), he attempted a logical analysis of trinitarian relations and explored the philosophical problems surrounding God's claims to omnipotence and omniscience. The Collationes (“Debates,” also known as “Dialogue between a Christian, a Philosopher and a Jew”; probably c.1130) present a rational investigation into the nature of the highest good, in which the Christian and the Philosopher (who seems to be modeled on a philosopher of pagan antiquity) are remarkably in agreement. The unfinished Scito teipsum (“Know thyself,” also known as the “Ethics”; c.1138) analyses moral action. (shrink)

Clinical mental health researchers may understandably struggle with how to incorporate biological assessments in clinical research. The options are numerous and are described in a vast and complex body of literature. Here we provide guidelines to assist mental health researchers seeking to include biological measures in their studies. Apart from a focus on behavioral outcomes as measured via interviews or questionnaires, we advocate for a focus on biological pathways in clinical trials and epidemiological studies that may help clarify pathophysiology and (...) mechanisms of action, delineate biological subgroups of participants, mediate treatment effects, and inform personalized treatment strategies. With this paper we aim to bridge the gap between clinical and biological mental health research by (1) discussing the clinical relevance, measurement reliability, and feasibility of relevant peripheral biomarkers; (2) addressing five types of biological tissues, namely blood, saliva, urine, stool and hair; and (3) providing information on how to control sources of measurement variability. (shrink)

This book is a rich blend of analyses by leading experts from various cultures and disciplines. A compact introduction to a complex field, it illustrates biotechnology's profound impact upon the environment and society. Moreover, it underscores the vital relevance of cultural values. This book empowers readers to more critically assess biotechnology's value and effectiveness within both specific cultural and global contexts.

In this loosely organized study Hyma undertakes to correct almost every misstatement made about Luther in recent years. Although some of the individual items will be of interest to Luther specialists, the work as a whole makes no clear impression.--R. F. T.

Wathāʾiq madīnat al-Qaṣr bi-l-wāḥāt al-Dakhla: Maṣdarān li-taʾrīkh Miṣr fī l-ʿaṣr al-ʿuthmānī. Silsilat Dirāsāt Wathāʾiqiyya. By Rudolph Peters. Cairo: Maṭbaʿat al-ʿĀmma li-Dār al-Kutub wa-l-Wathāʾiq al-Qawmiyya, 2011. Pp. 610.

Contents Preface General Introduction 1 | Science and Pseudoscience Introduction Karl Popper, Science: Conjectures and Refutations Thomas S. Kuhn, Logic of Discovery or Psychology of Research? Imre Lakatos, Science and Pseudoscience Paul R. Thagard, Why Astrology Is a Pseudoscience Michael Ruse, Creation-Science Is Not Science Larry Laudan, Commentary: Science at the Bar---Causes for Concern Commentary 2 | Rationality, Objectivity, and Values in Science Introduction Thomas S. Kuhn, The Nature and Necessity of Scientific Revolutions Thomas S. Kuhn, Objectivity, Value Judgment, and (...) Theory Choice Ernan McMullin, Rationality and Paradigm Change in Science Larry Laudan, Kuhn’s Critique of Methodology Helen E. Longino, Values and Objectivity Kathleen Okruhlik, Gender and the Biological Sciences Commentary 3 | The Duhem-Quine Thesis and Underdetermination Introduction Pierre Duhem, Physical Theory and Experiment W. V. Quine, Two Dogmas of Empiricism Donald Gillies, The Duhem Thesis and the Quine Thesis Larry Laudan, Demystifying Underdetermination *Colin Howson and Peter Urbach, The Duhem Problem Commentary 4 | Induction, Prediction, and Evidence Introduction Peter Lipton, Induction Karl Popper, The Problem of Induction Wesley C. Salmon, Rational Prediction Carl G. Hempel, Criteria of Confirmation and Acceptability Peter Achinstein, Explanation v. Prediction: Which Carries More Weight? *Nelson Goodman, The New Riddle of Induction Commentary 5 | Confirmation and Relevance: Bayesian Approaches Introduction Wesley C. Salmon, Rationality and Objectivity in Science *Deborah G. Mayo, A Critique of Salmon’s Bayesian Way *Alan Chalmers, The Bayesian Approach Paul Horwich, Therapeutic Bayesianism Commentary 6 | Models of Explanation Introduction Rudolf Carnap, The Value of Laws: Explanation and Prediction Carl G. Hempel, Two Basic Types of Scientific Explanation Carl G. Hempel, The Thesis of Structural Identity Carl G. Hempel, Inductive-Statistical Explanation Peter Railton, A Deductive-Nomological Model of Probabilistic Explanation *Philip Kitcher, Explanatory Unification *James Woodward, The Manipulability Conception of Causal Explanation Commentary 7 | Laws of Nature Introduction A. J. Ayer, What Is a Law of Nature? Fred I. Dretske, Laws of Nature D. H. Mellor, Necessities and Universals in Natural Laws Nancy Cartwright, Do the Laws of Physics State the Facts? Commentary 8 | Intertheoretic Reduction Introduction Ernest Nagel, Issues in the Logic of Reductive Explanations Paul K. Feyerabend, How to Be a Good Empiricist *Jerry A. Fodor, Special Sciences Philip Kitcher, 1953 and All That: A Tale of Two Sciences Commentary 9 | Empiricism and Scientific Realism Introduction Grover Maxwell, The Ontological Status of Theoretical Entities Bas C. van Fraassen, Arguments Concerning Scientific Realism Alan Musgrave, Realism versus Constructive Empiricism Larry Laudan, A Confutation of Convergent Realism *Juha T. Saatsi, On the Pessimistic Induction and Two Fallacies Ian Hacking, Experimentation and Scientific Realism David B. Resnik, Hacking’s Experimental Realism *Martin Carrier, What Is Right with the Miracle Argument Arthur Fine, The Natural Ontological Attitude Alan Musgrave, NOA’s Ark---Fine for Realism Commentary Glossary Bibliography Name Index Subject Index. (shrink)

English summary: It seems that reason is less a universal principle than something inherently bound to the contexts in which it appears. These contributions to a conference held on the occasion of Christoph Schwobel's 60th birthday explore the character of reason's manifold contexts: the grounding of reason in the inner word of God 's Trinitarian life as well as the disclosure of reason and and its limits in human conversation. German description: Vernunft scheint in der Gegenwart weniger ein allgemeines Prinzip (...) als eine in Kontexte eingebundene Grosse zu sein. Die Beitrage einer Tagung anlasslich von Christoph Schwobels 60. Geburtstag, gehen der Frage nach dem Charakter dieser Kontextbindung nach: der Begrundung der Vernunft im trinitarischen Gesprach wie der Erschliessung und Problematisierung der Vernunft im menschlichen Gesprach. Mit Beitragen von V. Brummer, G. van den Brink, C. Drobe, H. J. Eckstein, D.-M. Grube, J. Halfwassen, S. Heine, F. Hermanni, E. Herms, W. Harle, W. Homolka, W. Jeanrond, R. W. Jenson, D. Kelsey, A. F. Koch, A. Kupsch, V. Leppin, P.-C. Lai, P. Lo, A. Min, J. Moltmann, M. Muhling, P. Peterson, M. Sarot, F. Schweitzer, A. Torrance, J. Webster, M. Welker, M. Wendte, M. Wisse, H. Wisskirchen und L. Zak. (shrink)

In people with chronic low back pain, maladaptive structural and functional changes on a cortical level have been identified. On a functional level, somatosensory cortical excitability has been shown to be reduced in chronic pain conditions, resulting in cortical disinhibition. The occurrence of structural and/or functional maladaptive cortical changes in people with CLBP could play a role in maintaining the pain. There is currently no measurement protocol for cortical excitability that employs stimulation directly to the lower back. We developed a (...) protocol for the measurement of single pulse somatosensory evoked potential waveforms and paired-pulse behavior generated from sensory nerves of the lower back and quantified its test–retest reliability in a sample of 30 healthy individuals to gain insights into the normal variability of cortical responses, which could then be compared to results from people with CLBP. We investigated cortical excitability by measuring SEPs and PPB. PPB was defined as the ratio of the amplitude of the second cortical response divided by the first cortical response. A2s was determined by subtracting the response to single-pulse stimuli from the paired pulse stimuli response to account for linear superposition effects. The test–retest reliability of the protocol was very poor with no evidence of systematic bias but a high amount of random variability between sessions. There was no significant difference in the right side PPB for session 1 and session 2 ; mean session difference [ = −0.44 ; t = −1.17, p = 0.26]. The ICC3.1 for the outlier-removed right side PPB were 0.19 and 0.43 for left side PPB. This finding potentially has wider implications for PPB protocols. If these findings were replicated in other groups and other nerves, it would question the validity of this measure more generally. However, these findings are restricted to healthy people and sensory nerves of the lower back and may not be generalizable. (shrink)

"[R]easons for action must have their source in goals, desires, or intentions....[T]he possession of rationality is not sufficient to provide a source for relevant reasons,...certain desires, goals, or intentions are also necessary." ;So says Gilbert Harman. So say many other philosophers, from Aristotle to Hume to Harman and David Gauthier. To these many philosophers, this is a home truth, as obvious as the nose on your face. And yet as many philosophers---from the Stoics to Kant to Nagel and Korsgaard---reject this (...) view, and could not find it more obviously false. Any disagreement of this nature, which forces the disputants to find arguments for claims that seem to them self-evident and undeniable, is likely to generate a long, complicated and nasty war. Fortunately for the world, already subject to more fundamentalist clashes than one cares to count, this particular war stays mostly on paper and inside the walls of the academy, without any literal casualties. ;In this dissertation, I join the ranks of those who oppose Harman and his compatriots. I bring what I believe is a new strategy to the field of engagement. The strategy involves two stages. First, we are to undertake a thorough examination of what our opponents mean when they say that goals, desires, or intentions are the "source" of reasons; no one has ever satisfactorily cashed in this metaphor, and I propose to do so. The second stage follows naturally from the first, for in seeing what our opponents mean, we see a crucial weakness in their position: their troops are mercenary, and can be recruited to our side. The second stage is this recruitment. (shrink)